| Chronic fatigue syndrome (CFS), also | | | | Department of Health and Social Services |
| known as myalgic encephalomyelitis (ME), | | | | and the British Medical Association |
| post-viral fatigue syndrome (PVFS), and | | | | officially recognized it as a legitimate |
| various other names, is a syndrome (or | | | | and potentially distressing disorder. |
| group of syndromes) of unknown and | | | | Opponents of the term ME maintain there |
| possibly multiple etiologies, affecting | | | | is no inflammation, although there are |
| the central nervous system (CNS), immune, | | | | cases of CFS that present inflammation |
| and many other systems and organs. There | | | | (see Sophia Mirza). United Kingdom and |
| is no simple diagnostic test; CFS is a | | | | Canadian researchers and patients |
| diagnosis of exclusion, although recent | | | | generally use this term in preference to |
| research indicates biological hallmarks | | | | CFS. |
| of the syndrome, and a diagnostic test is | | | | Chronic fatigue syndrome (CFS); this |
| predicted soon. Most definitions (other | | | | name was introduced in 1988 by a group of |
| than the 1991 UK Oxford criteria[1]) | | | | United States researchers based at the |
| require a number of features, the most | | | | Centers for Disease Control and |
| common being severe mental and physical | | | | Prevention, and is used increasingly over |
| exhaustion or depletion which is | | | | other designations, particularly in the |
| "unrelieved by rest" (according to the |